Re: Big cuts coming : Thu Jul 09, 2020 1:00 pm  

Is Aids not a corona virus?

Re: Big cuts coming : Thu Jul 09, 2020 1:38 pm  

I don't think so. The common cold is though.

Re: Big cuts coming : Thu Jul 09, 2020 2:09 pm  

Sal Paradise wrote:

Is Aids not a corona virus?

AIDS isn't a virus.

HIV is a virus, a retrovirus (Lentivirus to be specific).

Corona virus's get their name because of what they look like - the sun with a corona. The spike protein on its surface looks like how a kid would draw the sun. (I know that's a daisy but you get the idea).

Re: Big cuts coming : Thu Jul 09, 2020 2:34 pm  

Jack Burton wrote:

I don't think so. The common cold is though.

Yes it is.

Re: Big cuts coming : Thu Jul 09, 2020 3:38 pm  

Thanks for clearing that up - have we ever found a cure for a virus? Or is building up immunity the only way of combatting them. If so why didn't we simply let herd immunity happen?

Re: Big cuts coming : Thu Jul 09, 2020 6:51 pm  

Sal Paradise wrote:

Thanks for clearing that up - have we ever found a cure for a virus? Or is building up immunity the only way of combatting them. If so why didn't we simply let herd immunity happen?

Absolutely we have eradicated virus's. Smallpox is gone - the vaccination program eliminated it. The vaccinations we now have protect us from severe cases of common virus's. Herd immunity is a genuine thing, but the ideal way to achieve it is though vaccination. For example, the MMR jab can't be given to babies, so you vaccinate everyone above the age of 2 and eliminate those diseases from the population (or close to eliminate). That way you protect babies - that's herd immunity. But with MMR it only works when very high levels of the population are vaccinated and immune - well over 80%. So basically almost everyone would have had to catch Covid 19 to create herd immunity - which sort of defeats the purpose. The chief epidemiologist who advised the govt was quizzed on this and it seems he may have been quoted out of context (a bit like what happens when people on here start arguing).

HIV is a tricky bugger. The protein it uses to attach to cells and infect them is called GP120 and it changes it's shape - hiding the critical bits that antibodies need to bind to to stop it infecting a cell. It also infects what are called CD4 T-Cells. These are called T Helper Cells and they are critical to the correct functioning of key parts of the immune system - including production of antibodies by B cells.
There are people who develop neutralizing antibodies (that stop the virus binding to the CD4 cells) to HIV but we haven't been able to recreate that with a vaccine. HIV has several other even more cunning ways of avoiding our immune system. But I believe we are making progress to a vaccine. In the meantime we have effective drugs to stop the virus multiplying. A lot of the work we are involved with in HIV studies (it's not extensive) is now looking at the long term biology of patients on drug therapies for HIV, these guys can be on drugs for 30 years plus now and live pretty much normal length lives.

Re: Big cuts coming : Fri Jul 10, 2020 7:58 am  

DHM wrote:

Absolutely we have eradicated virus's. Smallpox is gone - the vaccination program eliminated it. The vaccinations we now have protect us from severe cases of common virus's. Herd immunity is a genuine thing, but the ideal way to achieve it is though vaccination. For example, the MMR jab can't be given to babies, so you vaccinate everyone above the age of 2 and eliminate those diseases from the population (or close to eliminate). That way you protect babies - that's herd immunity. But with MMR it only works when very high levels of the population are vaccinated and immune - well over 80%. So basically almost everyone would have had to catch Covid 19 to create herd immunity - which sort of defeats the purpose. The chief epidemiologist who advised the govt was quizzed on this and it seems he may have been quoted out of context (a bit like what happens when people on here start arguing).

HIV is a tricky bugger. The protein it uses to attach to cells and infect them is called GP120 and it changes it's shape - hiding the critical bits that antibodies need to bind to to stop it infecting a cell. It also infects what are called CD4 T-Cells. These are called T Helper Cells and they are critical to the correct functioning of key parts of the immune system - including production of antibodies by B cells.
There are people who develop neutralizing antibodies (that stop the virus binding to the CD4 cells) to HIV but we haven't been able to recreate that with a vaccine. HIV has several other even more cunning ways of avoiding our immune system. But I believe we are making progress to a vaccine. In the meantime we have effective drugs to stop the virus multiplying. A lot of the work we are involved with in HIV studies (it's not extensive) is now looking at the long term biology of patients on drug therapies for HIV, these guys can be on drugs for 30 years plus now and live pretty much normal length lives.

Really interesting - thank you for that post

Re: Big cuts coming : Sat Jul 11, 2020 4:32 am  

how can you prepare for a virus you know nothing about and dont know is coming? prepare a vaccine for something you know nothing about?

Re: Big cuts coming : Sat Jul 11, 2020 11:16 pm  

Gotcha wrote:

Lets just see. I am not so naive with that. Sars vaccine would never have happened, regardless of dissapearing naturally. These things are never learned from. If it happens, then great all good, I just doubt it.

Oh you don’t think it would have happened. Even though the boffins say it would have? Ok so glad I’m in the company of an expert. Where did you get your phd in virology? Where can I get updates from you about the fight against covid 19 seeing as you are the self proclaimed expert?

Re: Big cuts coming : Sun Jul 12, 2020 5:45 am  

Steph Curry wrote:

Oh you don’t think it would have happened. Even though the boffins say it would have? Ok so glad I’m in the company of an expert. Where did you get your phd in virology? Where can I get updates from you about the fight against covid 19 seeing as you are the self proclaimed expert?

Oh grow up. I am no expert in either field. But it didn’t happen. The Far East still live in fear of it, but no vaccine. Therefore it never happening would put more probability on what I said than your petty response.

You could have simply backed up your patronising know it all post with substance like DHM, who does seem to know what he is talking about. But I doubt you actually know yourself.

Like I said previously, let’s all hope it happens this time, but I still very much doubt it. An history of these mistakes.