The league isn't massively strong at the moment so even with a few losses Wigan and Wire will still compete at the top end if the table. Leeds will be strong again, Huddersfield keep signing solid players and Saints have recruited well. Other then those 3 though there isn't a team capable of breaking the top 4 or 5 IMO.
The one thing I would say about you guys is you should have given more youngsters a chance by now when things have been good. It's easy for young players (well easier) to come in to a team full of experience then it is to come in to a side that has lost a lot of old heads. The depth of your squad has held them back a little IMO.
It is the end of one era for Wire but that's also an exciting time. The resource you have via Simon Moran will ensure you stay in the top 4 for a very long time IMO.