I cannot see any case whatsoever for remaining in the EU:
1. Economically it will continue to decline until it or unless it completely changes its modus operandi. It will destroy Britain's economy long-term by squeezing all innovation out - this has already happened in certain fields, eg drugs development, tech development, etc via centralised regulation. If it does dramatically reform then those who support it now for immature reasons like "workers rights" will be the first to complain.
2. Safer and more secure? Not a chance. The only "fact" is that Britain got dragged into two world wars due to forming alliances with other European states. Also, look at the uprisings (which we are only seeing the start of) in the poorer peripheral regions (which we will be in time if we stay in). Think of the potential future strife on the mass immigration of people from the Muslim world encouraged by Merkel. History strongly suggests this will result in bloodshed at some point in the future.
3. Getting out could stimulate growth and relieve poverty in Africa and other poorer regions as we could buy their produce more easily and more fairly.
4. It is utterly untenable for Cameron to pretend we can somehow be at the centre of the EU steering its development when we are not in the Eurozone. So that means the reasoners will have to sign us up to the destructive Eurozone in future. Why won't they say that? Could it be dishonesty - like our politicians have given us from the start if thus project?
To me the risks of staying in are enormous for the UK.